학술논문
Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns
Document Type
Academic Journal
Author
Source
AIDS. Dec 02, 2005 19(18):2167-2169
Subject
Language
English
ISSN
0269-9370
Abstract
The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants who were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).