학술논문
Changing of hepatitis C virus genotype patterns in France at the beginning of the third millenium: The GEMHEP GenoCII Study
Document Type
Academic Journal
Author
Payan, C.; Roudot-Thoraval, F.; Marcellin, P.; Bled, N.; Duverlie, G.; Fouchard-Hubert, I.; Trimoulet, P.; Couzigou, P.; Cointe, D.; Chaput, C.; Henquell, C.; Abergel, A.; Pawlotsky, J. M.; Hezode, C.; Coudé, M.; Blanchi, A.; Alain, S.; Loustaud-Ratti, V.; Chevallier, P.; Trepo, C.; Gerolami, V.; Portal, I.; Halfon, P.; Bourlière, M.; Bogard, M.; Plouvier, E.; Laffont, C.; Agius, G.; Silvain, C.; Brodard, V.; Thiefin, G.; Buffet-Janvresse, C.; Riachi, G.; Grattard, F.; Bourlet, T.; Stoll-Keller, F.; Doffoel, M.; Izopet, J.; Barange, K.; Martinot-Peignoux, M.; Branger, M.; Rosenberg, A.; Sogni, P.; Chaix, M. L.; Pol, S.; Thibault, V.; Opolon, P.; Charrois, A.; Serfaty, L.; Fouqueray, B.; Grange, J. D.; Lefrère, J. J.; Lunel-Fabiani, F.
Source
Journal of Viral Hepatitis. Jul 01, 2005 12(4):405-413
Subject
Language
English
ISSN
1352-0504
Abstract
This cross-sectional study aimed to investigate, during a short period between 2000 and 2001, in a large population of patients with chronic hepatitis C, the epidemiological characteristics of hepatitis C virus (HCV) genotypes in France. Data from 26 referral centres, corresponding to 1769 patients with chronic hepatitis C were collected consecutively during a 6-month period. HCV genotyping in the 5′-non-coding region (NCR) was performed in each center using the line probe assay (LiPA, in 63% of cases), sequencing (25%) or primer-specific polymerase chain reaction (PCR) (12%). HCV genotypes 1a, 1b, 2, 3, 4, 5, non-subtyped 1 and mixed infection were found in 18, 27, 9, 21, 9, 3, 11 and 1% of our population, respectively. HCV genotype distribution was associated with gender, age, source and duration of infection, alanine aminotransferase (ALT) levels, cirrhosis, alcohol consumption, hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection. In multivariate analysis, only the source of infection was the independent factor significantly associated with genotype (P = 0.0001). In conclusion, this study shows a changing pattern of HCV genotypes in France, with i.v. drug abuse as the major risk factor, an increase of genotype 4, and to a lesser extent 1a and 5, and a decrease of genotypes 1b and 2. The modification of the HCV genotype pattern in France in the next 10 years may require new therapeutic strategies, and further survey studies.