학술논문
An association between resistant hypertension and the null GSTM1 genotype
Document Type
Academic Journal
Author
Source
Journal of Human Hypertension. Aug 01, 2009 23(8):556-558
Subject
Language
English
ISSN
0950-9240
Abstract
Journal of Human Hypertension (2009) 23, 556-558; doi:10.1038/jhh.2009.19; published online 12 March 2009Reduction in expression levels of glutathione S-transferase (GST) μ type 1 (GSTM1) in stroke-prone spontaneously hypertensive rats has recently been reported. GSTM1 genotype was evaluated in 49 patients with resistant hypertension and compared with selected patients with controlled hypertension (n=232) and healthy participants (n=110). Null GSTM1 genotype occurred more frequent in patients with resistant hypertension than those with controlled hypertension (57.1 vs 39.7%; P=0.03; RR 1.96; 95% CI 1.04-3.69) suggesting that null GSTM1 genotype may predispose to resistant hypertension.