학술논문
Treatment of Resistant Obsessive-Compulsive Disorder With Ventral Capsular/Ventral Striatal Gamma Capsulotomy: A Pilot Prospective Study
Document Type
Academic Journal
Author
Lopes, Antonio Carlos; Greenberg, Benjamin D.; Norén, Georg; Canteras, Miguel Montes; Busatto, Geraldo F.; de Mathis, Maria Eugênia; Taub, Anita; DʼAlcante, Carina Chaubet; Hoexter, Marcelo Queiroz; Gouvea, Fernando Sauerbronn; Cecconi, Janaína Philippi; Gentil, André F.; Ferrão, Ygor Arzeno; Fuentes, Daniel; de Castro, Cláudio Campi; Leite, Cláudia C.; Salvajoli, João Victor; Duran, Fábio L. S.; Rasmussen, Steven; Miguel, Eurípedes Constantino
Source
The Journal of Neuropsychiatry and Clinical Neurosciences. Sep 15, 2009 21(4):381-392
Subject
Language
English
ISSN
0895-0172
Abstract
A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects.