학술논문
Coadministration of Coenzyme Q prevents Rosiglitazone-induced adipogenesis in ob/ob mice
Document Type
Academic Journal
Author
Source
International Journal of Obesity. Feb 01, 2009 33(2):204-211
Subject
Language
English
ISSN
0307-0565
Abstract
OBJECTIVE:: The aim of this study is to determine the effect of coenzyme Q (Q) on ob/ob mice treated or not with thiazolidinedione (TZD). DESIGN AND MEASUREMENTS:: Ob/ob mice were treated with Q, Rosiglitazone or a combination of both molecules for 13 days; physical and metabolic parameters as well as oral glucose tolerance test were assessed. mRNA expression of genes of energy dissipation and storage were measured by real-time PCR. RESULTS:: Q treatment improved some metabolic parameters in ob/ob mice. Surprisingly, cotreatment with Rosiglitazone and Q improved metabolic parameters and prevented TZD increase in body weight and adiposity, mainly by increasing lipid oxidation in adipose tissue, reducing lipid synthesis and balancing adipokine gene expression. CONCLUSIONS:: Our finding suggests that Rosiglitazone and coenzyme Q bitherapy could prevent the body weight gain associated with adipogenesis and could improve the clinical use of these compounds.International Journal of Obesity (2009) 33, 204-211; doi:10.1038/ijo.2008.265; published online 6 January 2009