학술논문
Antenatal determination of fetal rhesus (RH) D status using cell free fetal DNA in the maternal circulation before 20 weeksʼ gestation: is routine application practical and beneficial?
Document Type
Academic Journal
Author
Source
Archives of Disease in Childhood: Fetal and Neonatal Edition. Jun 01, 2011 96(Suppl_1 Suppl 1):Fa11-Fa12
Subject
Language
English
ISSN
1359-2998
Abstract
Analysis of free fetal DNA (cffDNA) in D- pregnant womensʼ blood can predict fetal D type. NICE recommended evaluation of this technology to spare D– women carrying a D– fetus exposure to anti-D, with potential savings to the NHS. Here we describe implementation at 28 weeks and evaluate effectiveness, costs and benefits before 20 weeks. METHODS: D- mothers attending seven hospitals in England were invited to have blood taken for cffDNA analysis of fetal RHD status at booking, Downʼs syndrome screening and the 20 week anomaly scan. If inconclusive or a D+ fetus was predicted, anti-D was given. Mothers predicted to have a D- fetus had repeat cffDNA testing at 28 weeks when it is know to be accurate (Finning BMJ 2008;336:816–8). Where D- status was confirmed anti-D was withheld. D type was confirmed by cord blood testing. RESULTS: Preliminary results are shown in the .(Table is included in full-text article.) CONCLUSIONS: Implementation of routine cffDNA testing for fetal D status in D- mothers will be possible from 11 weeks gestation with associated reduction in anti-D administration of around 40%. Evidence suggests this will be cost effective and favourably received by mothers who are keen to avoid anti-D if possible.