부산대학교 도서관

Introduction: Identifying clinical characteristics predictive of the development of thoracic aortic disease (TAD) and abdominal aortic aneurysms (AAA) would be valuable as these diseases are typically silent until potentially fatal complications develop. Prior studies have demonstrated increased prevalence of simple renal cysts (SRC) and bovine aortic arch (BAA) among patients with aortic disease. The aim of our study, on the contrary, was to evaluate the prevalence of aortic disease among patients with SRC and BAA compared to a control population without these characteristics.Methods: We performed a retrospective electronic medical record search for patients who underwent both chest and abdominal computed tomography (CT) imaging at our institution from 2012-2016. Patients with SRC and BAA were propensity score matched to those without these features by age, gender, hypertension, hyperlipidemia, diabetes, and chronic kidney disease.Results: We identified 35,498 patients, of whom 6,366 (17.9%) were identified as having a SRC by a radiologist. Compared to a propensity score matched population without SRC, individuals with SRC were significantly more likely to have TAD (10.1% vs. 3.9%, OR 2.76), ascending aortic aneurysm (8.0% vs. 3.2%, OR 2.65), descending aortic aneurysm (3.3% vs. 0.9%, OR 3.53), Type A aortic dissection (0.6% vs. 0.2%, OR 2.54), Type B aortic dissection (1.1% vs. 0.3%, OR 3.63), and AAA (7.9% vs. 3.3%, OR 2.55). Additionally, our search identified 920 (2.6%) patients with a BAA, as determined by a radiologist. These patients were significantly more likely to have TAD (21.8% vs. 4.5%, OR 5.99), ascending aortic aneurysm (18.4% vs. 3.2%, OR 6.91), descending aortic aneurysm (6.5% vs. 2.0%, OR 3.50), Type A aortic dissection (1.4% vs. 0.4%, OR 3.28), and Type B aortic dissection (2.4% vs. 0.7%, OR 3.73) than a propensity matched control population without BAA. On multivariable analysis, SRC and BAA were found to be significantly associated with the presence of TAD (OR = 2.57 and 7.69, respectively) and AAA (OR = 2.81 and 2.56, respectively).Conclusions: This study establishes a substantial increased prevalence of aortic disease among patients with SRC and BAA. SRC and BAA should be considered markers for aortic aneurysm development.