부산대학교 도서관

Skytte A-B, Crüger D, Gerster M, Lænkholm A-V, Lang C, Brφndum-Nielsen K, Andersen MK, Sunde L, Kφlvraa S, Gerdes A-M. Breast cancer after bilateral risk-reducing mastectomy.This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.