학술논문
Robotic synthesis of 6-[18F]fluoro-L-dopa
Document Type
Academic Journal
Author
Source
Nuclear Medicine Communications. Sep 01, 2000 21(9):799-802
Subject
Language
English
ISSN
0143-3636
Abstract
The aim of this study was to develop a method of semi-automated 6-[F]fluoro-L-dopa (6-[F]FDOPA) synthesis using a robotic system (Scanditronix Anatech RB III, Uppsala, Sweden). [F]Fluorine was produced via Ne(d,α)F using a Scanditronix MC17F cyclotron (Uppsala). The radiosynthesis was performed by the Scanditronix Anatech RB III robotic system. On average, a typical run produced 16-19 mCi of 6-[F]FDOPA at end of synthesis (EOS) after 2 h irradiation of the F2/neon gas target. The total synthesis time was 110 min. The retention time of 6-[F]FDOPA (the radio peak) was 8.2 min, which was consistent with the 6-[F]FDOPA ultraviolet peak. The radiochemical purity was greater than 97%. A robotic, semi-automated method for 6-[F]FDOPA radiosynthesis is therefore feasible. The radiation burden for the operator can be reduced as much as possible. Sufficient activity of 6-[F]FDOPA could be obtained for positron emission tomography studies of dopaminergic function.