학술논문
P194Serum uric acid as independent predictor of decreased number of circulating proangiogenic progenitor cells in asymptomatic coronary artery disease patients
Document Type
Academic Journal
Author
Source
Cardiovascular Research. Jul 15, 2014 103(suppl_1 Suppl 1):S34-S34
Subject
Language
English
ISSN
0008-6363
Abstract
Background: Serum uric acid (SUA) plays a pivotal role in the pathogenesis of cardiovascular diseases affecting xanthine oxidase pathway that contributes to the production of active oxygen species generation. Vascular oxidative stress and endothelial dysfunction contribute an injury of both cardiomyocytes and vascular endothelium that requires an activation of reparation processing. However, several types of circulating progenitor cells (CPCs) mediate an angiogenesis and tissue repair following injuries. Few studies have investigated the association of hyperuricemia with subclinical heart failure and atherosclerosisThe aim of this study was to determine whether serum uric acid (SUA) is an independent predictor of the decreased number of CPC of in asymptomatic CAD patients.Design and Methods: 126 subjects (54 male), aged 48 to 62 years, and with asymptomatic CAD documented previously with angiography, and 25 healthy volunteers were enrolled in the study. Concentration of SUA was measured with enzymatic methods. The flow cytometric technique was used for predictably distinguishing cell subsets that depend on the expression of CD14, CD34, Tie-2, CD45, and CD309 (VEGFR2).Results: The analysis of the outcome obtained shows a trend of decrease of circulating CD45-CD34+ CMCs and a reduction of number of CMCs defined as CD14+CD309+ and CD14+CD309+Tie2+ in known asymptomatic CAD patients in comparison with healthy volunteers. Substantial correlations between number of both CD14+CD309+ and CD14+CD309+Tie2+ and conventional cardiovascular risk factors (hs-CRP, T2DM, SUA and hypertension) were found in the patient cohort. Univariate regression analysis showed that T2DM (RR = 1.21; 95% CI = 1.10–1.40; P = 0.008), hs-CRP > 2.54 mg/L (RR = 1.29; 95% CI = 1.12–1.58; P = 0.006), Agatston score index (RR = 1.2095% CI = 1.15–1.27; P = 0.034), SUA > 459 mmol / L (RR = 1.31; 95% CI = 1.12–1.49; P = 0.008) were factors that associated with decreased both CD14+CD309+ and CD14+CD309+Tie2+ CPCs. In multivariate model SUA> 459 mmol / L had independent predicted value (RR = 1.18; 95% CI = 1.04–1.27; P = 0.001) for decreased CPCs defined as CD14+CD309+ and CD14+CD309+Tie2+.Conclusion: Serum uric acid is independently associated with lowed circulating CD14+ CD309+ and CD14+CD309+Tei2+ cells in asymptomatic patients with known CAD.