부산대학교 도서관

INTRODUCTION: The adverse impact of acute hyperglycemia is well documented but its specific effects on non-diabetic trauma patients are unclear. The purpose of this study was to analyze the differential impact of hyperglycemia on outcomes between diabetic and non-diabetic trauma inpatients. METHODS: Adults admitted 2018-19 to 46 Level I/II trauma centers with >2 blood glucose tests (BGT) were analyzed. Diabetes status was determined from ICD-10, trauma registry and/or HbA1c >6.5. Patients with and without >1 hyperglycemic result >180 mg/dL were compared. Logistic regression examined the effects of hyperglycemia and diabetes on outcomes, adjusting for age, gender, ISS & BMI. RESULTS: There were 95,764 patients: male 54%, mean age 61, mean ISS 10, diabetic 21%. Patients with hyperglycemia had higher mortality and worse outcomes compared to those without hyperglycemia. Non-diabetic hyperglycemic patients had the highest odds of mortality (Diabetic: aOR: 3.11, 95% CI: 2.8-3.5, Non-diabetics aOR: 7.5, 95% CI: 6.8-8.4). Hyperglycemic non-diabetics experienced worse outcomes on every measure when compared to non-hyperglycemic non-diabetics, with higher rates of sepsis (1.1 vs 0.1%, P < .001), more SSIs (1.0 vs 0.1%, P < .001), longer mean hospital LOS (11.4 vs. 5.0, P < .001), longer mean ICU LOS (8.5 vs. 4.0, P < .001), higher rates of ICU use (68.6% vs. 35.1), and more ventilator use (42.4% vs. 7.3%). CONCLUSIONS: Hyperglycemia is associated with increased odds of mortality in both diabetic and non-diabetic patients. Hyperglycemia during hospitalization in non-diabetics was associated with the worst outcomes and represents a potential opportunity for intervention in this high-risk group. LEVEL OF EVIDENCE: Level II (therapeutic/care management)