학술논문
Pandemic 2009 Influenza A in Argentina: A Study of 337 Patients on Mechanical Ventilation
Document Type
Academic Journal
Author
Estenssoro, Elisa; Ríos, Fernando G.; Apezteguía, Carlos; Reina, Rosa; Neira, Jorge; Ceraso, Daniel H.; Orlandi, Cristina; Valentini, Ricardo; Tiribelli, Norberto; Brizuela, Matías; Balasini, Carina; Mare, Sebastián; Domeniconi, Gustavo; Ilutovich, Santiago; Gómez, Alejandro; Giuliani, Javiera; Barrios, Cecilia; Valdez, Pascual
Source
American Journal of Respiratory and Critical Care Medicine. Jul 01, 2010 182(1):41-48
Subject
Language
English
ISSN
1073-449X
Abstract
RATIONALE:: OBJECTIVES:: METHODS:: MEASUREMENTS AND MAIN RESULTS:: Proportions of confirmed, probable, or suspected cases were 39%, 8%, and 53% and had similar outcomes. APACHE II was 18 ± 7; age 47 ± 17 years; 56% were male; and 64% had underlying conditions, with obesity (24%), chronic obstructive respiratory disease (18%), and immunosupression (15%) being the most common. Seven percent were pregnant. On admission, patients had severe hypoxemia ( 140 [87-200]), extensive lung radiologic infiltrates (2.87 ± 1.03 quadrants) and bacterial coinfection, (25%; mostly with Streptococcus pneumoniae). Use of adjuvants such as recruitment maneuvers (40%) and prone positioning (13%), and shock (72%) and acute kidney injury requiring hemodialysis (17%), were frequent. Mortality was 46%, and was similar across all ages. APACHE II, lowest , shock, hemodialysis, prone positioning, and S. pneumoniae coinfection independently predicted death.(Figure is included in full-text article.) CONCLUSIONS