부산대학교 도서관

AIM:: To analyse the influence of apolipoprotein (APOE) ϵ4 status on the cognitive and behavioural functions usually impaired after moderate and severe traumatic brain injury (TBI). METHODS:: In all, 77 patients with TBI selected from 140 consecutive admissions were genotyped for APOE. Each patient was subjected to neuropsychological and neurobehavioural assessment at least 6 months after injury. RESULTS:: Performance of participants carrying the ϵ4 allele was notably worse on verbal memory (Auditory Verbal Learning Test), motor speed, fine motor coordination, visual scanning, attention and mental flexibility (Grooved Pegboard, Symbol Digit Modalities Test and part B of the Trail Making Test) and showed considerably more neurobehavioural disturbances (Neurobehavioral Rating Scale—Revised) than the group without the ϵ4 allele. CONCLUSIONS:: In particular, performance on neuropsychological tasks that are presumed to be related to temporal lobe, frontal lobe and white matter integrity is worse in patients with the APOE ϵ4 allele than in those without it. More neurobehavioural disturbances are observed in APOE ϵ4 carriers than in APOE ϵ2 and ϵ3 carriers.