학술논문
Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort:the ELAPSE project
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Electronic Resource
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Chen , J , Rodopoulou , S , Strak , M , de Hoogh , K , Taj , T , Poulsen , A H , Andersen , Z J , Bellander , T , Brandt , J , Zitt , E , Fecht , D , Forastiere , F , Gulliver , J , Hertel , O , Hoffmann , B , Hvidtfeldt , U A , Verschuren , W M M , Jorgensen , J T , Katsouyanni , K , Ketzel , M , Lager , A , Leander , K , Liu , S , Ljungman , P , Severi , G , Boutron-Ruault , M-C , Magnusson , P K E , Nagel , G , Pershagen , G , Peters , A , Rizzuto , D , van der Schouw , Y T , Samoli , E , Sørensen , M , Stafoggia , M , Tjønneland , A , Weinmayr , G , Wolf , K , Brunekreef , B , Raaschou-Nielsen , O & Hoek , G 2022 , ' Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort : the ELAPSE project ' , British Journal of Cancer , vol. 126 , pp. 1499–1507 .
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Abstract
BACKGROUND: The evidence linking ambient air pollution to bladder cancer is limited and mixed.METHODS: We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O-3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) in a pooled cohort (N = 302,493). Exposures were primarily assessed based on 2010 measurements and back-extrapolated to the baseline years. We applied Cox proportional hazard models adjusting for individual- and area-level potential confounders.RESULTS: During an average of 18.2 years follow-up, 967 bladder cancer cases occurred. We observed a positive though statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93-1.27) per 5 mu g/m(3) for 2010 exposure and 1.06 (95% CI: 0.99-1.14) for baseline exposure. Effect estimates for NO2, BC and O-3 were close to unity. A positive association was observed with PM2.5 zinc (HR 1.08; 95% CI: 1.00-1.16 per 10 ng/m(3)).CONCLUSIONS: We found suggestive evidence of an association between long-term PM2.5 mass exposure and bladder cancer, strengthening the evidence from the few previous studies. The association with zinc in PM2.5 suggests the importance of industrial emissions.