학술논문

Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
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Electronic Resource
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Source
Salanti , A , Dahlbäck , M , Turner , L , Nielsen , M A , Barfod , L , Magistrado , P , Jensen , A T R , Lavstsen , T , Ofori , M F , Marsh , K , Hviid , L & Theander , T G 2004 , ' Evidence for the involvement of VAR2CSA in pregnancy-associated malaria ' , Journal of Experimental Medicine , vol. 200 , no. 9 , pp. 1197-203 .
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article
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Abstract
Udgivelsesdato: 2004-Nov-1
In Plasmodium falciparum-endemic areas, pregnancy-associated malaria (PAM) is an important health problem. The condition is precipitated by accumulation of parasite-infected erythrocytes (IEs) in the placenta, and this process is mediated by parasite-encoded variant surface antigens (VSA) binding to chondroitin sulfate A (CSA). Parasites causing PAM express unique VSA types, VSAPAM, which can be serologically classified as sex specific and parity dependent. It is sex specific because men from malaria-endemic areas do not develop VSAPAM antibodies; it is parity dependent because women acquire anti-VSAPAM immunoglobulin (Ig) G as a function of parity. Previously, it was shown that transcription of var2csa is up-regulated in placental parasites and parasites selected for CSA binding. Here, we show the following: (a) that VAR2CSA is expressed on the surface of CSA-selected IEs; (b) that VAR2CSA is recognized by endemic plasma in a sex-specific and parity-dependent manner; (c) that high anti-VAR2CSA IgG levels can be found in pregnant women from both West and East Africa; and (d) that women with high plasma levels of anti-VAR2CSA IgG give birth to markedly heavier babies and have a much lower risk of delivering low birth weight children than women with low levels.