부산대학교 도서관

Skeletal muscle is a sophisticated, hierarchically bundled tissue that is responsible for contracting to produce force within the body. Such muscle possesses a remarkable capacity to regenerate throughout adult life – an ability that is attributable to the contribution of muscle stem cells. Although satellite cells represent the primary, physiological muscle stem cell, other cell types exist that can contribute to myogenesis under varying circumstances. The cell fate decisions of satellite cells are influenced by multiple levels of regulation in vivo, and in‐vitro culture systems have only just begun to scratch the surface of employing various soluble, physical, and substrate factors to mimic the physiological microenvironment and augment muscle stem cell proliferation in culture.