학술논문
'Is the bright red patch on the roof of my mouth related to the purple splotches on my back?'
Document Type
eBook
Author
Source
HIV, ill.
Subject
Language
English
Abstract
Kaposi’s sarcoma (KS) is an important differential diagnosis for skin lesions in individuals living with HIV/AIDS that may also present systemic manifestations. KS is the most common AIDS-associated cancer (ADC) worldwide. KS was initially described in 1981 among young men wo have sex with men in USA. Since then, we have learned that Kaposi Sarcoma Herpes Virus (KSHV), also called Human Herpes Virus 8 (HHV8) is necessary but not sufficient factor to develop KS. Replication of each virus, HIV and KSHV/HHV8, can be enhanced in the presence of the other while adaptive immune response plays an important role to control KS. KSHV/HHV8 is the causative agent of a spectrum of diseases Kaposi Sarcoma (KS), Multicenter Cattleman's Disease (MCD), Pleural Effusion Lymphoma (PEL). Late presentation to care at the time of HIV diagnosis is still a significant risk for opportunistic infections and ADCs.