학술논문
전이성 융모상피암 항암화학요법 중 발생한 자연기흉
A Case of Spontaneous Pneumothorax During Chemotherapy for Metastatic Choriocarcinoma
A Case of Spontaneous Pneumothorax During Chemotherapy for Metastatic Choriocarcinoma
Document Type
Article
Author
이향 / Hyang Lee; 강무삼 / Mu Sam Kang; 이삼미 / Sam Mi Lee; 김문홍 / Moon Hong Kim; 김성일 / Seong Il Kim; 최석철 / Seok Cheol Choi; 유상영 / Sang Young Ryu; 이경희 / Kyung Hee Lee
Source
Obstetrics & Gynecology Science. Sep 30, 2002 45(9):1633
Subject
Language
Korean
ISSN
2287-8572
Abstract
자연기흉은 전이성 폐암과 관련된 합병증으로서 드물게 보고되고 있으며 항암요법에 효과적인 골육종, 원발성 폐암, 생식세포종 등에 대해 항암요법 후에 종종 보고 되어지고 있다. 강력한 항암요법이 종양조직의 괴사를 유도하고 그 재생과정을 방해함으로서 발현성, 혹은 잠재성의 폐 전이 환자에서 기흉의 발생빈도를 증가시키는 것으로 생각되고 있다. 이에 저자 등은 융모상피암 환자에서 항암요법과 관련되어 발생한 자연기흉 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.
Spontaneous pneumothorax is a rare complication of pulmonary metastatic disease, most often following chemotherapy for osteogenic sarcomas, primary lung cancer or malignant germ cell tumors. Intensive chemotherapy may theoretically increase the risk of pneumothorax in patients with manifest or occult lung metastases by inducing rapid lysis of the tumor tissue and by interfering with repair processes. We present a case of patient with spontaneous pneumothorax after the introduction of chemotherapy for metastatic choriocarcinoma and review the literature and discuss the possible pathophysiologic mechanisms.
Spontaneous pneumothorax is a rare complication of pulmonary metastatic disease, most often following chemotherapy for osteogenic sarcomas, primary lung cancer or malignant germ cell tumors. Intensive chemotherapy may theoretically increase the risk of pneumothorax in patients with manifest or occult lung metastases by inducing rapid lysis of the tumor tissue and by interfering with repair processes. We present a case of patient with spontaneous pneumothorax after the introduction of chemotherapy for metastatic choriocarcinoma and review the literature and discuss the possible pathophysiologic mechanisms.