학술논문
난소의 악성배세포종양에 관한 임상병리학적 고찰
A Clinicopathologic Study of Ovarian Malignant Germ Cell Tumor
A Clinicopathologic Study of Ovarian Malignant Germ Cell Tumor
Document Type
Article
Author
유상영 / Sang Young Ryu; 강순범 / Soon Beom Kang; 이철민 / Chul Min Lee; 김재원 / Jae Won Kim; 박노현 / Noh Hyun Park; 송용상 / Yong Sang Song; 이효표 / Hyo Pyo Lee
Source
Obstetrics & Gynecology Science. Dec 30, 1998 41(12):3023
Subject
Language
Korean
ISSN
2287-8572
Abstract
From Jan. 1984 to Dec. 1993, 46 patients with malignant germ cell tumor of ovary were identified in tumor registry of Seoul National University Hospital. The clinicopathologic features of these patients were reviewed. The mean age of patient was 21.6 years (range 1-54), and common presenting symptoms were abdominal mass (19/46), abdominal pain (9/46), abdominal distension (7/46), and epigastric discomfort (2/46) in order. Dysgerminoma was the most common histologic type (19/46, 41.3%), followed by endodermal sinus tumor (13/46, 28.2%), mixed germ cell tumor (6/46, 13/0%), embryonal carcinoma(5/46, 10.8%), immature teratoma(2/46, 4.3%), and chorio- carcinoma (1/46, 2.1%). Among 6 mixed germ cell tumors, dysgerminoma mixed with endodermal sinus tumor component was the most frequent combination. Fifty percent of patients were with FIGO stage I, and 26% with stage III. Overall two year disease free survival was 89.1%. Patients with dysgerminoma showed more favorable 2 year disease free survival (100%) than endodermal sinus tumor or mixed germ cell tumor (84.6%, 66.6% respectively). Patients age, disease stage, histologic type and future child-bearings should be considered in the management of malignant ovarian germ cell tumor. Multicenter prospective randomized studies are needed to identify the more rational treatment strateges of these rare malignant tumors.