부산대학교 도서관

Background/Aims: The approval of sofosbuvir (SOF), a direct- acting antiviral, has revolutionized the treatment of chronic hepatitis C virus (HCV). Methods: We assessed the sustained virological response (SVR) of SOF-based regimens in a real- world single-center setting for the treatment of chronic HCV genotype 1 (G1) patients. This was a retrospective review of chronic HCV G1 adult patients treated with a SOF-based regi-men at Virginia Mason Medical Center between December 2013 and August 2015. Results: The cohort comprised 343 patients. Patients received SOF+ledipasvir (LDV) (n=155), SOF+simeprevir (SIM) (n=154), or SOF+peginterferon (PEG)+ribavirin (RBV) (n=34). Of the patients, 50.1% (n=172) had cirrhosis. The SVR rate was 92.2% for SOF/LDV, 87.0% for SOF/SIM, and 82.4% for SOF/PEG/RBV. Compared with the cirrhotic patients, the patients without cirrhosis had a higher SVR (96.8% vs 85.5%, p=0.01, SOF/LDV; 98.2% vs 80.6%, p=0.002, SOF/SIM; 86.4% vs 75.0%, p=0.41, SOF/ PEG/RBV). In this study, prior treatment experience adversely affected the response rate in subjects treated with SOF/ PEG/RBV. Conclusions: In this single-center, real-world set-ting, the treatment of chronic HCV G1 resulted in a high rate of SVR, especially in patients without cirrhosis. (Gut Liver 2017;11:711-720)