부산대학교 도서관

Tissue macrophages serve trophic functions, maintain tissue homeostasis, and mediate resolution of inflammation. As monocytes provide a macrophage precursor pool, the total population of monocytes and macrophages comprises a maintenance and defense pool that is involved in many human diseases, including obesity. In recent years, emerging evidence has shown that after infection or vaccination, prototypical innate immune cells (such as monocytes, macrophages, or natural killer cells) display long-term changes in their functional programs. Fine-tuned epigenetic processes that tightly regulate cellular differentiation and their responses under different challenges control the great plasticity of these cells. These epigenetic marks form the basis of the histone code, which postulates that the type and number of histone tail modifications specify transcriptional memory and biological outcomes. This talk would briefly review the hypothesis that trained immunity might be a major mechanism of metabolic memory and sustained inflammation.