학술논문
류마티스 관절염에서 발생한 Cerebral Aspergillosis
A Case of Cerebral Aspergillosis in a Patients with Rheumatoid Arthritis
A Case of Cerebral Aspergillosis in a Patients with Rheumatoid Arthritis
Document Type
Article
Author
이태근 / Tae Kun Lee; 최재훈 / Jae Hoon Choi; 최철웅 / Cheul Woong Choi; 이상용 / Sang Yong Lee; 이준희 / Jun Hee Lee; 이정욱 / Joung Wook Lee; 김상수 / Sang Soo Kim; 김성일 / Sung Il Kim
Source
Journal of Rheumatic Diseases(구 대한류마티스학회지). Dec 30, 2003 10(4):438
Subject
Language
Korean
ISSN
2093-940X
Abstract
저자들은 류마티스관절염으로 장기간 치료 중이던 환자에서 정위 뇌조직 검사로 뇌 aspergillosis 1예를 경험하였기에 보고하는 바이다.
We report a case of aspergillosis of the central nervous system in patient with rheumatoid arthritis (RA). A 46-year-old woman with 20-year history of RA and on treatment with corticosteroid, hydroxychloroquine and methotrexate, was admitted because of drowsiness, dizziness and dysarthria. On admission, physical examination and laboratory data showed, among other findings, disappearance of pupil reflex, positive Babinski and Chaddock reflex. Magnetic resonance imaging (MRI) of brain showed multiple high signal intensity lesion on medulla, pons, midbrain, basal ganglia, internal capsule, thalamus and hypothalmus. Stereotactic brain biopsy was performed and biopsy specimen revealed an invasive Aspergillus.
We report a case of aspergillosis of the central nervous system in patient with rheumatoid arthritis (RA). A 46-year-old woman with 20-year history of RA and on treatment with corticosteroid, hydroxychloroquine and methotrexate, was admitted because of drowsiness, dizziness and dysarthria. On admission, physical examination and laboratory data showed, among other findings, disappearance of pupil reflex, positive Babinski and Chaddock reflex. Magnetic resonance imaging (MRI) of brain showed multiple high signal intensity lesion on medulla, pons, midbrain, basal ganglia, internal capsule, thalamus and hypothalmus. Stereotactic brain biopsy was performed and biopsy specimen revealed an invasive Aspergillus.