부산대학교 도서관

Background/Aims: We sought to examine whether the pres-ence of gallstone disease (GD) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) is associated with liver fibrosis and histological nonalcoholic steatohepatitis (NASH) score. Methods: We included 441 Turkish patients with biopsy-proven NAFLD. GD was diagnosed in the pres-ence of sonographic evidence of gallstones, echogenic mate-rial within the gallbladder with constant shadowing and little or no visualization of the gallbladder or absence of gallblad-der at ultrasonography, coupled with a history of cholecys-tectomy. Results: Fifty-four patients (12.2%) had GD (GD+ subjects). Compared with the GD- subjects, GD+ patients were older, had a higher body mass index and were more likely to be female and have metabolic syndrome. However, GD+ patients did not have a higher risk of advanced fibrosis or definite NASH on histology. After adjustment for potential confounding variables, the prevalence of GD in NAFLD pa-tients was not associated with significant fibrosis (≥2) (odds ratio [OR], 1.06; 95% confidence interval [CI], 0.53 to 2.21; p=0.68) or definite NASH (OR, 1.03; 95% CI, 0.495 to 2.12; p=0.84). Conclusions: The presence of GD is not indepen-dently associated with advanced fibrosis and definite NASH in adult Turkish patients with biopsy-proven NAFLD.(Gut Liver 2014;8:313-317)