부산대학교 도서관

Background: Acid-suppressive medication (ASM), such as proton pump inhibitors and histamine 2 receptor antagonists, are commonly used. However, concerns have been raised that they might cause allergic diseases, including asthma. We investigated the relationship between the use of ASM and the subsequent incidence of asthma. Methods: A retrospective cohort study was conducted using the data from health insurance claims and results of specific health checkups for metabolic syndrome from 3 health insurance societies April 2011-thru-March 2015. Among the 40-64-year-old subjects without asthma (5,915 men, 3,973 women), logistic regression analyses were performed to investigate the relationship between the use of ASM (stratified as none, 1-59 days/year, ≥60days/year) and subsequent incidence of asthma. The adjustment was made for age, smoking status, BMI, and registered “allergic rhinitis” and “reflux esophagitis” diagnoses in multivariate logistic regression analyses. Results: 213 (3.6%) men (median 47 [IQR, 11] years old) and 211 (5.3%) women (median 47 [IQR, 9]) developed asthma. In the whole cohort, both short- and long-term use of ASM was significantly related to asthma incidence (adjusted Odds Ratio 1.89 [95% CI, 1.40-2.57]; P <0.001, aOR 1.82 [95% CI, 1.15-2.89]; P = 0.01, respectively). In men, only short-term use of ASM was significantly related to asthma incidence (aOR 1.87 [95% CI, 1.21-2.92]; P = 0.005). In women, both short- and long-term use was significantly related to asthma incidence (aOR 1.92 [95% CI, 1.26-2.92]; P = 0.002, aOR 2.85 [95% CI, 1.50-5.40]; P = 0.001, respectively). Longer duration of ASM use was also significantly associated with asthma incidence after adjusting for confounders (P-values for trends <0.001 in women and the whole cohort). Results in subjects without registered “reflux esophagitis” were almost the same as in the main analyses. Conclusions: Acid- suppressive medication could be a risk factor for the subsequent incidence of asthma.