학술논문
Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea
Document Type
Article
Author
Sukdong Yoo; Min Hyun Cho; Hee Sun Baek; Ji Yeon Song; Hye Sun Lee; Eun Mi Yang; Kee Hwan Yoo; Su Jin Kim; Jae Il Shin; Keum Hwa Lee; Tae-Sun Ha; Kyung Mi Jang; Jung Won Lee; Kee Hyuck Kim; Heeyeon Cho; Mee Jeong Lee; Jin-Soon Suh; Kyoung Hee Han; Hye Sun Hyun; Il-Soo Ha; Hae Il Cheong; Hee Gyung Kang; Mee Kyung Namgoong; Hye-Kyung Cho; Jae-Hyuk Oh; Sang Taek Lee; Kyo Sun Kim; Joo Hoon Lee; Young Seo Park; Seong Heon Kim
Source
Kidney Research and Clinical Practice(구 대한신장학회지). Dec 31, 2021 40(4):673
Subject
Language
Korean
ISSN
2211-9132
Abstract
Background: The clinical features of pediatric rhabdomyolysis differ from those of the adults with rhabdomyolysis; however, multicenter studies are lacking. This study aimed to investigate the characteristics of pediatric rhabdomyolysis and reveal the risk factors for acute kidney injury (AKI) in such cases. Methods: This retrospective study analyzed the medical records of children and adolescents diagnosed with rhabdomyolysis at 23 hospitals in South Korea between January 2007 and December 2016. Results: Among 880 patients, those aged 3 to 5 years old composed the largest subgroup (19.4%), and all age subgroups were predominantly male. The incidence of AKI was 11.3%. Neurological disorders (53.6%) and infection (39.0%) were the most common underlying disorder and cause of rhabdomyolysis, respectively. The median age at diagnosis in the AKI subgroup was older than that in the non-AKI subgroup (12.2 years vs. 8.0 years). There were no significant differences in body mass index, myalgia, dark-colored urine, or the number of causal factors between the two AKI-status subgroups. The multivariate logistic regression model indicated that the following factors were independently associated with AKI: multiorgan failure, presence of an underlying disorder, strong positive urine occult blood, increased aspartate aminotransferase and uric acid levels, and reduced calcium levels. Conclusion: Our study revealed characteristic clinical and laboratory features of rhabdomyolysis in a Korean pediatric population and highlighted the risk factors for AKI in these cases. Our findings will contribute to a greater understanding of pediatric rhabdomyolysis and may enable early intervention against rhabdomyolysis-induced AKI.