학술논문
Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal
Document Type
Article
Source
Journal of Neurogastroenterology and Motility. Jul 31, 2017 23(3):341
Subject
Language
English
ISSN
2093-0879
Abstract
Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed. (J Neurogastroenterol Motil 2017;23:341-348)