부산대학교 도서관

Objective: To identify risk factors of HSIL and cervical cancer in women with ASC-H Methods: A retrospective chart review of 155 patients who had ASC-H and underwent conization between 2013 and 2022. Clinical factors (age, parity, body weight, height, medical history, prior history of abdominal surgery, and complete blood counts within 1week of conization), and pathologic results (type of HPV infection, punch biopsy results, and pathologic reports of conization) are recruited. Results: Total 122 women diagnosed as HSIL (≥CIN2) by punch biopsy or conization. Women with HSIL was significantly correlated with younger age (<45 years old), non-multiparity, non-menopause, no prior abdominal surgery, high-risk HPV infection, and higher neutrophil to lymphocyte (NLR) ratio (≥ 2.0) than those without HSIL (＜CIN2). Multiple logistic regression revealed that high-risk HPV infection (Hazard ratio 4.709; 95% Confidence interval 1.541~14.391; P= 0.007) and no prior abdominal history (Hazard ratio 4.047; 95% CI (1.409~11.628; P= 0.009) were high risk factors for HSIL in women with ASC-H. Conclusion: Direct conization might be preferred when women with ASC-H also have high-risk HPV infection and no history of abdominal surgery.