학술논문
액체크로마토그래피-텐덤질량분석법에 의한 하천수 및 정수 중 남조류 기원 신종 독소 BMAA(β-N-Methylamino-L-Alanine)의 정량분석
Determination of β-N-Methylamino-L-Alanine (BMAA) Levelsin Surface Water and Treated Water by Liquid Chromatography-Tandem Mass Spectrometry
Determination of β-N-Methylamino-L-Alanine (BMAA) Levelsin Surface Water and Treated Water by Liquid Chromatography-Tandem Mass Spectrometry
Document Type
Article
Author
Source
환경분석과 독성보건 / Journal of Environmental Analysis, Health and Toxicolog. Dec 31, 2021 24(4):172
Subject
Language
Korean
English
English
ISSN
2672-0175
Abstract
β-Methylamino-L-alanine(BMAA)isanemergingalgaltoxinthathasdrawnattentionbecauseitcancauseneurodegenerativediseases,includingParkinson'sdiseaseandAlzheimer'sdisease(AD).Therefore,itisnecessarytodevelopasensitiveanalyticalmethodforBMAA,anemergingcyanobacterialtoxin,todeterminewhetheratraceamountisdetectedinthewaterresourcesandtreatedwater.Inthisstudy,wedevelopedasimpleandsensitiveanalyticalmethodforBMAAusingliquidchromatography-tandemmassspectrometry(LC-MS/MS)withdirectinjection.Themethodwasvalidatedforlinearityofcalibration,limitofdetection,limitofquantitation,accuracy,andprecision.Thelimitsofdetectionandquantitationwereintherangeof0.030?/Land0.096?/L,respectively.TheoptimizedmethodwasusedtomeasuretheconcentrationsofBMAAinsurfacewaterfromeachweirpointoftheGeumRiver,NakdongRiver.SamplingandanalysisofdrinkingwatertreatmentplantsoftheGeumRiver,NakdongRiverwereappliedtosamplesforeachprocess.