부산대학교 도서관

Objective: To develop a therapeutic agent for obesity-related metabolic disorders, a mixture of dietary components was prepared, including Fomitipsis pinicola Jeseng extract, Acanthopanax sessiliflorus extract,Viscum album var. coloratum extract and Allium tuberosum extract (FAVA), and its effects on obesity, hyperlipidemia and non-alcoholic fatty liver disease examined. Methods: C57BL/6J mice were fed a normal or high-fat diet with FAVA or saline (control) treatment during 12 weeks. We measured body weight, averages of food intake per week and tissue weights. And we analyzed blood biochemical parameters and hormones. We also performed CT scanning images of whole body fat accumulation. And we checked effect of FAVA on gene expressions related to adipocyte differentiation, cholesterol synthesis and fatty acid oxidation in epididymal adipose tissue. Moreover, we tested effect of FAVA on hepatic stetosis in liver tissue by H&E staining. Results: The FAVA dramatically inhibited the high-fat diet (HFD)-induced increase in body weight and fat in C57BL/6 mice, whereas food consumption was not affected by FAVA treatment. The FAVA also suppressed the HFDinduced increase in serum lipids. In addition, liver steatosis were returned to normal by FAVA treatment in HFD-fed C57BL/6 mice. The serum levels of insulin and leptin were also significantly down-regulated by FAVA treatment. Furthermore, FAVA decreased gene expression levles of adipocyte differentiation and cholesterol synthesis and increseaed gene expression levles of fatty acid oxidationin compared to the HFD control group.These results suggest that FAVA suppressed HFD-induced obesity, hyperlipidemia and nonalcoholic fatty liver disease. Conclusion: FAVA supplementation might be a promising adjuvant therapy for the treatment of these metabolic disorders.