부산대학교 도서관

Oxidative stress and inflammation are common to manypathological conditions. Defense mechanisms protect cellsfrom oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factorsregulate proinflammatory and antioxidant gene expression, respectively. Studies have shown that many natural dietary compounds regulate NF-κB and Nrf2, preventing in flammationand oxidative stress. Here, we report major compounds of Prunella vulgaris var. lilacina such as rosmarinic acid, oleanolic acid, ursolic acid and caffeic acid as a potential therapeutic for oxidative stress and inflammation. The majorcompounds exhibited high anti-inflammatory activity, inhibiting NO, PGE2 production, NF-κB expression and activating Nrf2expression. In addition, we examined the effect of majorcompounds on MafK expression. Among the compounds, oleanolic acid significantly decreased MafK expression and MafK-mediated p65 acetylation. These findings suggest thatoleanolic acid as NF-κB inhibitors can potentially be used in therapeutic applications for the treatment of oxidative stressnduceddiseases.