부산대학교 도서관

Background: It is shown that the variability of distance between QT derivations in twelve derivation ECG; is risk factor for sudden death as a predictor of cardiovascular mortality in both diabetic and general population. Diabetic nephropathy is one of the most common complication of diabetes. The purpose was to investigate the relationship between QT parameters and microalbumin/creatinine ratio; as an indicator of endothelial function and a cardiovascular risk factor. Methods: 100 patients were included our study who were follow up Istanbul Education and Research Hospital Diabetes Outpatient Clinic. 50 patients whose microalbumin/ creatinine ratio less than 30 mg/dl and ages between 36 and 77 years were chosen as control group; 50 patients whose microalbumin/ creatinine ratio between 30- 300 mg/dl and ages between 36 and 79 years were chosen as patient group. The QT interval was measured on the 12-lead resting ECG. QTd was calculated automatically using special software. Results: In patients group QTC min median value was higher; 380,63(361,44-397,30), (p=0,042),QTC max median value was significantly higher; 439,63(420,17-460,22), (p=0,005) and microalbumin/creatinine value 82(60-300), (p=0,0001) was very signifi cantly higher than control group. There was no signifi cant difference QTC dispersion median value 61,25(49,91-81,70, (p=0,066) in both groups. Also a good correlation in positive direction between QTC dispersion values and microalbumin/creatinine value was determined. Conclusions: We researched the relation between microalbumin/creatinine ratio and QTd levels in type 2 diabetic patients. QTc max period was determined signifi cantly high in the group with microalbumin/creatinine between 30-300 mg/dl (p<0,05). As a result of this correlation QT prolongation can be use as a contributory parameter for prediction of cardiovascular risk. This study make us that QTd can be used as early indicator of cardiovascular risk in diabetic patients who aren`t in microalbuminuric stage yet.