학술논문
항결핵제유발 간 손상에서 인터루킨-10과 전환성장인자- 베타1 유전다형태
Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury
Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury
Document Type
Article
Author
정소담 / Sodam Jung; 김상훈 / Sang-hoon Kim; 손장원 / Jang Won Sohn; 윤호주 / Ho Joo Yoon; 신동호 / Dong Ho Shin; 지영구 / Young-koo Jee; 김상헌 / Sang-heon Kim
Source
Allergy asthma & respiratory disease. Jan 30, 2017 5(1):41
Subject
Language
Korean
ISSN
2288-0402
Abstract
Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of medications. Previously, IL-10 gene polymorphism has been reported to be associated with diclofenac-induced hepatitis. In this study, we aimed to investigate the associations between genetic polymorphisms of immune-regulating cytokines (IL-10 and TGF-β1) with antituberculosis drugs (ATD)-induced liver injury. Methods: We enrolled 80 patients with ATD-induced liver injury and 238 ATD-tolerant controls. Two single nucleotide polymorphisms (SNP) of IL-10 (-1082A>G, rs1800896; -819T>C, rs1800871) and one promoter SNP of TGF-β1 gene (-509C>T, rs1800469) were genotyped in both groups. Genotype frequencies of these SNPs were compared between case and control groups. Results: In 2 promoter SNPs of IL-10 gene, there was no significant difference of genotype frequencies between patients with ATD-induced liver injury and controls. In addition, the genotype frequency of TGF-β1 -509C>T SNP in ATD-induced liver injury patients were not different from those of controls. Conclusion: In conclusion, there was no significant association between IL-10 and TGF-β1 gene polymorphisms and ATD-induced liver injury. These findings suggest that IL-10 and TGF-β1 do not play important role in the development of ATD-induced liver injury. (Allergy Asthma Respir Dis 2017:5:41-46)