학술논문
Alginic Acid Sodium Salt 도포가 가토 외안근의 조정력에 미치는 영향
The Effect of Alginic Acid Sodium Salt on Delayed Adjustable Strabismus Surgery
The Effect of Alginic Acid Sodium Salt on Delayed Adjustable Strabismus Surgery
Document Type
Article
Author
Source
대한안과학회지 / Journal of The Korean Ophthalmological Society. Jul 15, 2000 41(7):1493
Subject
Language
Korean
ISSN
0378-6471
Abstract
사시수술 후 지연조정술의 시기를 연장하기 위한 여러 방법이 연구되고 있다. 저자는 해조류에서 추출한 생체적합성 천연고분자인 alginic acid sodium salt를 이용한 지연조정술 시기의 연장효과를 알아보고자 하였다. 1.5~2 kg의 백색 가토 15마리의 양안에 hang-back techniqu을 시행하고 한쪽 눈에만 4%alginic acid sodium salt 0.1 cc를 근육과 공막사이, 근육과 결막사이에 도포하고 반대편 눈은 도포하지 않았다. 수술 후 3일, 5일, 7일, 10일, 14일에 지연조정술을 행하고 조정에 필요한 인력 및 조정된 거리를 측정하였다. 각 시기마다 광학현미경으로 섬유조직의 증식정도를 관찰하였다. 15마리 30안 중 alginic acid sodium salt를 사용하지 않고 hang-back technique만 시행한 1군은 14안이었으며 alginic acid sodium salt를 사용한 2군은 1 안이었다. 평균 조정력은 수술시 alginic acid sodium salt를 사용한 2군이 사용하지 않은 1군보다 통계적으로 유의하게 적게 나타났다(p=0.0078). 평균 조정거리는 alginic acid sodium salt를 사용한 2군이 사용하지 않은 1군보다 통계적으로 유의하게 높게 나타났다(p=0.0236). 조직학적 소견에서 alginic acid sodium salt를 사용하지 않은 1군이 alginic acid sodium salt를 사용한 2군보다 더 심한 섬유화 소견을 보였다. 이상의 결과에서 alginic acid sodium salt는 사시수술 후 지연조정술 시기의 연장에 효과적인 물질로 생각된다 (한안지 41:1493~1498,2000).
The purpose of this study was to evaluate the effect of the alginic acid sodium salt on the delayed adjustable strabismus surgery by preventing the post operative tissue adhesion.30 eyes of 15 rabbits had received an adjustable suture surgery. The alginic acid sodium salt of 4% was used during operation in 16 eyes among them by injecting it around the muscle, between the sclera and the conjunctiva. In the 3rd, 5th, 7th, 10th, and 14th day postoperatively, we measured the pulling forces and the moving distances of the muscles during the adjustment. Then the eyes were enucleated and the histopathologic changes of the eyes were determined using the light microscope. The pulling forces and the moving distances of the muscles during the adjustment were significantly different between the alginic acid sodium salt free group and the alginic acid sodium salt used group. In the alginic acid sodium salt used group, the pulling forces were decreased and the moving distances were increased than those of the alginic acid sodium salt free group. The light microscopic examination showed more fibrosis in the alginic acid sodium salt free group than in the alginic acid sodium salt used group. These results suggest that the alginic acid sodium salt is an effective substance for the delayed adjustable suture surgery(J Korean Ophthalmol Soc 41:1493~1498,2000).
The purpose of this study was to evaluate the effect of the alginic acid sodium salt on the delayed adjustable strabismus surgery by preventing the post operative tissue adhesion.30 eyes of 15 rabbits had received an adjustable suture surgery. The alginic acid sodium salt of 4% was used during operation in 16 eyes among them by injecting it around the muscle, between the sclera and the conjunctiva. In the 3rd, 5th, 7th, 10th, and 14th day postoperatively, we measured the pulling forces and the moving distances of the muscles during the adjustment. Then the eyes were enucleated and the histopathologic changes of the eyes were determined using the light microscope. The pulling forces and the moving distances of the muscles during the adjustment were significantly different between the alginic acid sodium salt free group and the alginic acid sodium salt used group. In the alginic acid sodium salt used group, the pulling forces were decreased and the moving distances were increased than those of the alginic acid sodium salt free group. The light microscopic examination showed more fibrosis in the alginic acid sodium salt free group than in the alginic acid sodium salt used group. These results suggest that the alginic acid sodium salt is an effective substance for the delayed adjustable suture surgery(J Korean Ophthalmol Soc 41:1493~1498,2000).