학술논문
마크로글로불린혈증을 동반한 림프절 변연부 B세포 림프종
A case of nodal marginal zone B-cell Lymphoma with macroglobulinemia
A case of nodal marginal zone B-cell Lymphoma with macroglobulinemia
Document Type
Article
Author
이봉규 / Bong Kyu Lee; 강미자 / Mi Ja Kang; 이정수 / Jeong Soo Lee; 황선호 / Seon Ho Whang; 기영화 / Young Hwa Ki; 강원유 / Won Yu Kang; 고향미 / Hyang Mi Go
Source
대한내과학회지 (Korean J Med) / The Korean Journal of Medicine (Korean J Med). Oct 01, 2005 69(4):441
Subject
Language
Korean
ISSN
1738-9364
Abstract
저자들은 임상적, 조직학적, 면역학적으로 확인된 단클론성 감마글로불린혈증(IgM, Kappa)이 아직까지 별로 알려지지 않은 림프절 변연부 B세포 림프종에서도 동반된 예를 경험하였으며, 앞으로 더 많은 예에서 다른 이상이 발견될 것으로 기대된다.
Macroglobulinemia is the result of an uncontrolled proliferation of lymphocytes and plasma cells in which a large IgM M protein is produced. IgM monoclonal gammopathy is recognized in a variety of lymphoproliferative diseases and Waldenstrom`s macroglobulinemia (WM) is the most frequent disease in this group. We report a case of nodal marginal zone B-cell lymphoma (Nodal MZBCL) accompanied by monoclonal macroglobulinemia. A 58-year-old man was admitted to the hospital with chronic fatigue and dyspnea. Physical examination revealed cervical, subaxillary, and inguinal lymphadenopathy. Histopathologically, monocytoid B cells with abundant pale cytoplasm and small nuclei infiltrated the cervical lymph node. The neoplastic cells were positive for CD 20, bcl-2, and IgM. The serum and urine electrophoresis showed monoclonal spike in the globulin region and immunoelectrophoresis demonstrated immunoglobulin of IgM, kappa type. Immunohistochemically, this monoclonal gammaglobulinemia (IgM, Kappa) was produced and secreted from the nodal MZBCL. This is the first report of nodal MZBCL accompanying macroglobulinemia in Korea.(Korean J Med 69:441-445, 2005)
Macroglobulinemia is the result of an uncontrolled proliferation of lymphocytes and plasma cells in which a large IgM M protein is produced. IgM monoclonal gammopathy is recognized in a variety of lymphoproliferative diseases and Waldenstrom`s macroglobulinemia (WM) is the most frequent disease in this group. We report a case of nodal marginal zone B-cell lymphoma (Nodal MZBCL) accompanied by monoclonal macroglobulinemia. A 58-year-old man was admitted to the hospital with chronic fatigue and dyspnea. Physical examination revealed cervical, subaxillary, and inguinal lymphadenopathy. Histopathologically, monocytoid B cells with abundant pale cytoplasm and small nuclei infiltrated the cervical lymph node. The neoplastic cells were positive for CD 20, bcl-2, and IgM. The serum and urine electrophoresis showed monoclonal spike in the globulin region and immunoelectrophoresis demonstrated immunoglobulin of IgM, kappa type. Immunohistochemically, this monoclonal gammaglobulinemia (IgM, Kappa) was produced and secreted from the nodal MZBCL. This is the first report of nodal MZBCL accompanying macroglobulinemia in Korea.(Korean J Med 69:441-445, 2005)