학술논문
위의 CD56 음성 자연살해 T세포 림프종 1예
Gastric CD56-negative Extranodal Natural Killer/T-cell Lymphoma: A Case Report
Gastric CD56-negative Extranodal Natural Killer/T-cell Lymphoma: A Case Report
Document Type
Article
Author
정주홍 / Joohong Chung; 지삼룡 / Sam Ryong Jee; 최은정 / Eunjeong Choi; 유승정 / Seung Jung Yu; 윤준식 / Jun Sik Yoon; 이홍섭 / Hong Sub Lee; 이상헌 / Sang Heon Lee; 박성재 / Sung Jae Park; 박하영 / Ha Young Park
Source
대한소화기학회지 / The Korean Journal of Gastroenterology. Oct 31, 2022 80(4):190
Subject
Language
Korean
ISSN
1598-9992
Abstract
Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL-NT) is the most common subtype of Epstein-Barr virus-associated NK/T-cell lymphomas. ENKTCL-NT occurs infrequently in the gastrointestinal tract. In particular, reports of ENKTCL-on NT arising from the stomach are extremely rare. Several clusters of differentiation (CDs) have been useful in recognizing NK-cells, T-cells, and tumor cells of NK/T-cell lymphomas. Among them, the CD56 antigen is considered the most sensitive marker for ENKTCL-NT and is expressed in almost all cases of ENKTCL-NT. Thus, the development of CD56-negative ENKTCL-NT is highly atypical. This paper reports a case of a young Asian female who presented with gastric ulcer bleeding. The patient was histologically diagnosed with ENKTCL-NT. No tumor cells for CD56 were observed, whereas no monoclonality of the T-cell receptor gamma gene rearrangement was detected in the tumor cells. The patient was scheduled for systemic chemotherapy six times and achieved complete remission. Peripheral blood-hematopoietic stem cell transplantation was performed later. (Korean J Gastroenterol 2022;80: 190-194)