학술논문
이달의 X-선 : 항암화학치료 후 발생한 항이뇨호르몬 부적절 분비 증후군 1예
Image of the Month : A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Chemotherapy in a Patient with Non-Small-Cell Lung Cancer
Image of the Month : A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Chemotherapy in a Patient with Non-Small-Cell Lung Cancer
Document Type
Article
Author
이경주 / Kyoung Ju Lee; 문재영 / Jae Young Moon; 이승룡 / Sung Yong Lee; 이상엽 / Sang Yeub Lee; 김제형 / Je Hyeong Kim; 신철 / Chol Shin; 심재정 / Jae Jeong Shim; 인광호 / Kwang Ho In; 강경호 / Kyung Ho Kang; 유세화 / Se Hwa Yoo
Source
Tuberculosis and Respiratory Diseases. Apr 30, 2009 66(4):324
Subject
Language
Korean
ISSN
1738-3536
Abstract
상기 환자는 진행성 비소세포폐암으로 진단 받고 carboplatin과 gemcitabine의 전신적 항암치료 후에 전신 쇠약 동반한 저나트륨혈증으로 병원에 내원하여 SIADH로 진단 받고 carboplatin 약제 중단 후 호전되었다. 이러한 항암제투여 후에 유발된 SIADH는 여러 가지 원인과의 감별을 요하며, carboplatin에 의해 유발된 SIADH의 보고는 드물기에 증례로 이를 문헌 고찰과 함께 보고하는 바이다.
The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.
The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.