부산대학교 도서관

The purpose of the present study is to develop a zwitterionic and pseudozwitterionic organic materials which can overcome the limitations of existing antibiofouling coating agents for the gold and poly(ethylene terephthalate) (PET) substrates. Previous studies utilized zwitterionic polymer to prevent the biofouling on the surface of gold and PET substrates. However, because of complexed, high cost, and unstable coating method, necessity of developing new organic coating agents were continuously raised. Therefore, in this study, zwitterionic and pseudozwitterionic organic materials which can easily and stably immobilize on the gold and poly(ethylene terephthalate) (PET) substrates and introduce antibiofouling properties were developed. First, zwitterionic small molecule bearing disulfide moiety was successfully synthesized in one-pot process which was monitored by UV-visible spectroscopy, and it was easily immobilized to the gold substrate, which was evaluated by contact angle measurement and X-ray photoelectron spectroscopy (XPS), by submerging it to the coating solution. Also, it successfully inhibited the bovine-serum albumin (BSA) proteins on gold substrate. Second, pseudozwitterionic copolymer which can immobilize to the PET substrate by UV irradiation was synthesized. PET substrates coated with pseudozwitterionic copolymer and various controls were characterized by contact angle measurement, zeta-potential analysis, and XPS. Finally, antibiofouling performance was evaluated by fibroblast and platelet adhesion test which demonstrated excellent foulant repellent property. As a result, synthesized zwitterionic small molecule and pseudozwitterionic copolymer successfully immobilized to the gold and PET substrate, respectively, in simple and efficient method, and showed excellent antibiofouling performance.