부산대학교 도서관

Background: This study investigated the clinical characteristics and risk factors of the severity of pandemic influenza A (H1N1) 2009 infection in pediatric patients in Busan and Gyeongsangnam-do.Methods: Cases of influenza A (H1N1) 2009 in patients under the age of 18 years, confirmed by RT-PCR, at Pusan National University Hospital and Yangsan Pusan National University Hospital from the last week of August 2009 through the last week of February 2010 were retrospectively analyzed.Results: Of the 3,777 confirmed cases of influenza A (H1N1) 2009, 2,200 (58.2%) were male and 1,577 (41.8%) were female. The average age of the patients was 8.4±4.8 years. The total cases peaked during weeks 44 to 46. Most of the patients were in the 5- to 9-year-old age group. Oseltamivir was administered to 2,959 (78.3%) of the patients. 221 patients (5.9%) were hospitalized, with an average age of 6.7±4.5 years. The average duration of hospitalization was 7.4±5.6 days. 100 cases (45.2%) had pneumonia. The risk factors of hospitalization included male gender, < 2 years of age, and underlying disease, such as asthma and neurologic disorder. Ten of the patients (4.5%) were admitted to the intensive care unit, and eight (3.6%) required mechanical ventilation.Conclusion: Of the pediatric patients with pandemic influenza A (H1N1) 2009, most of the patients were in the 5- to 9-year-old age group. The risk factors of hospitalization included male gender, < 2 years of age, and underlying disease, such as asthma and neurologic disorder. The most common complication was pneumonia.Key words : Pandemic influenza A (H1N1), Clinical characteristics, Pediatric infection, Busan, Gyeongsangnam-do