부산대학교 도서관

AbstractThe effect of estimated glomerular filtration rate on clinical outcome in acute ischemic stroke patientsName: Mi-Yeon EunDepartment: NeurologyThesis Advisor: Professor Sungwook Yu MD, Ph.DBackgroundChronic kidney disease (CKD) is an established risk factor for cardiovascular disease and stroke. Patients with CKD have worse functional outcome and high mortality rate after stroke compared with those without CKD. We evaluated whether estimated glomerular filtration rate (eGFR) was an independent predictor of clinical outcomes after acute ischemic stroke. MethodsWe included consecutive patients with acute ischemic stroke from the prospective stroke registry in Korea University Anam Hospital. Patients with thrombolysis were excluded. Patients were categorized into five groups according to eGFR ≥ 90, 60-89, 45-59, 30-44, < 30 mL/min/1.73 m2. The effects of eGFR on poor functional outcome at discharge defined as modified Rankin Scale score of 3 to 6, in-hospital mortality, neurological deterioration, and hemorrhagic transformation were evaluated using logistic regression analyses. ResultsAmong 2254 patients, 1420 were included for analysis. There were 479 (33.7%) patients with poor functional outcome at discharge and 32 (2.3%) patients died during hospitalization. Neurological deterioration was observed in 54 (3.8%) patients and hemorrhagic transformation in 107 (7.5%) patients. In the univariate logistic regression analyses reduced eGFR was associated with poor functional outcome at discharge (p < 0.001) and in-hospital mortality (p = 0.001), but not with neurological deterioration (p = 0.532) and hemorrhagic transformation (p = 0.115). However, there were no significant associations between eGFR and any clinical outcomes in the multivariable analyses after adjustment of clinical and laboratory variables. ConclusionsReduced eGFR was associated with poor functional outcome at discharge and in-hospital mortality but not an independent predictor in patients with acute ischemic stroke.