부산대학교 도서관

Pseudomonas aeruginosa bacteremia is a serious and sometimes fatal condition. It is important to predict the probability of P. aeruginosa bacteremia when Gram-negative sepsis is suspected in community-onset infection.I performed a retrospective cohort study to identify the risk factors for mortality of patients with community-onset P. aeruginosa bacteremia and the risk factors for P. aeruginosa infection in community-onset Gram-negative bacteremia.A total of 106 patients with P. aeruginosa bacteremia and a total of 508 patients with E. coli bacteremia were included in this study. In P. aeruginosa bacteremia, malignancy (n=83, 78.3%) was the most common underlying disorder; fifty patients (47.2%) were neutropenic and 56 patients (52.8%) had septic shock. The 30-day mortality rate was 26.4% in patients with P. aeruginosa bacteremia. In multivariate analysis, a high Pitt bacteremia score and inappropriate initial antimicrobial therapy were found to be significant risk factors for 30-day mortality of patients with P. aeruginosa bacteremia. Clinical predictors associated with P. aeruginosa bacteremia in the multivariate analysis included presentation with neutropenia, presentation with septic shock, indwelling central venous catheter and healthcare-associated infection (all P