부산대학교 도서관

The objective of this study was to assess the impact of varying viscosities of silicone oil on the physical, chemical, and biological properties of a sodium iodide paste. To accomplish this, the researchers created six paste groups by combining therapeutic substances, namely sodium iodide (D30) and iodoform (I30), with calcium hydroxide and one of three viscosities of silicone oil (high (H), medium (M), and low (L)). They evaluated the performance of these groups using various parameters, including flow, film thickness, pH, viscosity, and injectability, and conducted statistical analysis (p < 0.05). The study revealed that the D30L group demonstrated notable improvements over the conventional iodoform-based paste. Significant reductions in osteoclast formation were observed through TRAP, c-FOS, NFATc1, and Cathepsin K analysis (p < 0.05). Moreover, analysis of mRNA sequencing data demonstrated that the I30L group displayed elevated expression levels of inflammatory genes and upregulated cytokines compared to the D30L group. These results suggest that the optimized viscosity of the sodium iodide paste (D30L) could contribute to slower root resorption, which is considered beneficial in primary teeth from a clinical standpoint. Based on the findings of the study, it can be determined that the D30L group demonstrates the most satisfactory outcomes, indicating its potential as a promising root filling material that could potentially replace conventional iodoform-based pastes.