부산대학교 도서관

In this study, Glutathione-responsive hydrogel, MIPs and their related NIPs were synthesized byprecipitation polymerization method. Effect of HEMA/MAA and EGDMA/TRIM as functional monomerand crosslinking agents on size, morphology, drug loading and releasing were studied. BACy as a disulfidecross-linking agent was used in praparation of Glutathione-responsive hydrogel. The size andmorphology of MIPs and NIPs were examined by FE-SEM technique. Results showed EGDMAsynthesizedMIPs had the smaller size than TRIM-prepared MIPs. In order to measure the capacity of MIPsor NIPs for binding to cisplatin, static and dynamic adsorption experiments were done. The amounts ofcisplatin were measured by HPLC method. The binding capacity of drug by MIPs is observed to be higherthan NIPs. The EGDMA-synthesized polymers showed a high percentage of adsorption. NIPs weresaturated much sooner than MIPs. In vitro release assays of cisplatin were done in PBS at pH = 7.4 andtemperature of 37 C. The results showed that increase of the amount of GSH cause to increase release ofthe drug from hydrogel.