부산대학교 도서관

Purpose We evaluated the residual vascular and adipose tissue inflammation in patients with chronic coronary artery disease(CAD) using positron emission tomography (PET). Methods Our study population consisted of 98 patients with known CAD and 94 control subjects who had undergone18F-fluorodeoxyglucose (18F-FDG) PET due to non-cardiac reasons. Aortic root and vena cava superior 18F-FDG uptakewere measured to obtain the aortic root target-to-background ratio (TBR). In addition, adipose tissue PET measurementswere done in pericoronary, epicardial, subcutaneous, and thoracic adipose tissue. Adipose tissue TBR was calculated usingthe left atrium as a reference region. Data are presented as mean ± standard deviation or as median (interquartile range). Results The aortic root TBR was higher in CAD patients compared to control subjects, 1.68 (1.55–1.81) vs. 1.53 (1.43–1.64),p < 0.001. Subcutaneous adipose tissue uptake was elevated in CAD patients 0.30 (0.24–0.35) vs. 0.27 (0.23–0.31), p < 0.001. Metabolic activity of CAD patients and control subjects was comparable in the pericoronary (0.81 ± 0.18 vs. 0.80 ± 0.16,p = 0.59), epicardial (0.53 ± 0.21 vs. 0.51 ± 0.18, p = 0.38) and thoracic (0.31 ± 0.12 vs. 0.28 ± 0.12, p = 0.21) adipose tissueregions. Aortic root or adipose tissue 18F-FDG uptake was not associated with the common CAD risk factors, coronarycalcium score, or aortic calcium score (p value > 0.05). Conclusion Patients with a chronic CAD had a higher aortic root and subcutaneous adipose tissue 18F-FDG uptake comparedto control patients, which suggests residual inflammatory risk.