학술논문

In-vitro Cytotoxicity Assessment of Mg-4Li-3Sn (LT43) Alloy with Structure-Property Correlation for Bio-Medical Applications
Document Type
Article
Source
Metals and Materials International, 29(7), pp.2093-2108 Jul, 2023
Subject
재료공학
Language
English
ISSN
2005-4149
1598-9623
Abstract
A promising biological alloy is required to support the concept of delivering sufficient mechanical properties with adequatecorrosion resistance for progressive deterioration without having any negative impacts on human body tissues. The combinedaction of the alloying elements (Li & Sn) in the current analysis offers a reliable solution to maintain the stable hcp structureof magnesium and enhances the electrochemical responsiveness of the LT43 (Mg-4Li-3Sn) alloy. The microstructural analysisof the as-cast LT43 Mg alloy shows the primary dendrites of the α-Mg (solid solution) and Mg2Snprecipitate. The completedissolution of Mg2Snoccurred after Solutionizing treatment at 400 °C for 3 h thereby allowing precipitation hardening tothe developed alloy. Furthermore, the effect of rolling at 300 °C for 5 min followed by isochronal treatment has a significantimpact on strain rate. Thermo-mechanical processing (hot rolling) has been carried out on LT43 Mg alloy with 60% reduction(HR60) and 90% reduction (HR90), and bio-corrosion investigations have been investigated in a simulated bodily fluid(SBF) environment. Compared to the alloy’s as-cast condition (4%, 130 MPa), the 90% reduced alloy has a ductility of 5%and an ultimate tensile strength of 213 MPa. Similar to the above, the corrosion rate (Rw) for samples with a 90% reductionshowed values of 1.869 mm/year, which is better than the rate for the as-cast condition (3.465 mm/year). The PotentiodynamicPolarization Test (PDP) revealed a lower rate of corrosion (0.49 mm/year). The cytotoxicity and Acridine Orange/Ethidium Bromide (AO/EB) staining performed on HEK-293 (Human Embryonic Kidney Cell Line) further demonstratedthat the LT43-HR90(TD) alloy was less harmful to human embryonic cells.