부산대학교 도서관

Due to the tumor immune escape mechanism, strategies like the utilization of bispecific antibodies wereused to assist immunotherapy. Herein a visible polymer–inorganic hybrid gene vehicle had beenprepared to deliver anti-EpCAM/anti-CD3 encoding minicircle DNA into normal cells thus thesetransfected cells effectively secreted bispecific antibody with bioactivity. In the experiments, thiscompound system exhibited excellent biocompatibility, high transfection efficiency and ultrasensitiveimaging capacity. Furthermore, the transfected cells could be detected under the MR imaging system andthe gene product showed an outstanding immune effect. In conclusion, this nanocomposite showedsynergistic advantages in gene delivery and non-invasive MR imaging.