부산대학교 도서관

Somatic cell nuclear transfer (SCNT) is a technology in which a somatic nucleus is transferred into thecytoplasm of a matured oocyte – reconstructed embryos have the capacity to develop to term. Why somaticcells can be reprogrammed by oocytes – the answer for this question must exist in the cytoplasm of maturedoocytes. In this review, totipotent characters of matured oocytes were discussed, which may confer maturedoocytes with the capacity to reprogram somatic nucleus. Moreover, the procedure of SCNT also makes apossibility for somatic nucleus to be reprogrammed by oocytes. Compared with fertilized embryos, embryosderived from SCNT exhibit low developmental ability; the barricades in reprogramming process and theirpossible reasons were also discussed. This review maybe can benefit the mechanism research of SCNTtechnology and can make contribution for improving the efficiency of this technology.