학술논문

Brown Adipose Tissue: Activation and Metabolism in Humans
Document Type
Article
Source
Endocrinology and Metabolism, 38(2), pp.214-222 Apr, 2023
Subject
내과학
Language
English
ISSN
2093-5978
2093-596X
Abstract
Brown adipose tissue (BAT) is a thermogenic organ contributing to non-shivering thermogenesis. BAT becomes active under coldstress via sympathetic nervous system activation. However, recent evidence has suggested that BAT may also be active at thermoneutrality and in a postprandial state. BAT has superior energy dissipation capacity compared to white adipose tissue (WAT) andmuscles. Thus, it has been proposed that the recruitment and activation of additional BAT may increase the overall energy-expendingcapacity in humans, potentially improving current whole-body weight management strategies. Nutrition plays a central role in obesity and weight management. Thus, this review discusses human studies describing BAT hyper-metabolism after dietary interventions. Nutritional agents that can potentially recruit brown adipocytes via the process of BAT-WAT transdifferentiation are also discussed.