학술논문
New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities
Document Type
Article
Author
Source
Bulletin of the Korean Chemical Society, 34(3), pp.827-830 Mar, 2013
Subject
Language
English
ISSN
1229-5949
0253-2964
0253-2964
Abstract
Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV- 1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 μg/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 μM, respectively.