학술논문
Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea
Document Type
Article
Author
유숙동; Cho Min Hyun; Baek Hee Sun; Song Ji Yeon; Lee Hye Sun; Yang Eun Mi; 유기환; Kim Su Jin; Shin Jae Il; Lee Keum Hwa; 하태선; Jang Kyung Mi; Lee Jung Won; 김기혁; Cho Heeyeon; 이미정; Suh Jin-Soon; Han Kyoung Hee; Hyun Hyesun; 하일수; 정해일; 강희경; 남궁미경; Cho Hye-Kyung; 오재혁; 이상택; Kim Kyo Sun; Lee Joo Hoon; Park Young Seo; Kim Seong Heon
Source
Kidney Research and Clinical Practice, 40(4), pp.673-686 Dec, 2021
Subject
Language
English
ISSN
2211-9140
2211-9132
2211-9132
Abstract
Background: The clinical features of pediatric rhabdomyolysis differ from those of the adults with rhabdomyolysis; however, multi- center studies are lacking. This study aimed to investigate the characteristics of pediatric rhabdomyolysis and reveal the risk factors for acute kidney injury (AKI) in such cases. Methods: This retrospective study analyzed the medical records of children and adolescents diagnosed with rhabdomyolysis at 23 hospitals in South Korea between January 2007 and December 2016. Results: Among 880 patients, those aged 3 to 5 years old composed the largest subgroup (19.4%), and all age subgroups were pre- dominantly male. The incidence of AKI was 11.3%. Neurological disorders (53.6%) and infection (39.0%) were the most common un- derlying disorder and cause of rhabdomyolysis, respectively. The median age at diagnosis in the AKI subgroup was older than that in the non-AKI subgroup (12.2 years vs. 8.0 years). There were no significant differences in body mass index, myalgia, dark-colored urine, or the number of causal factors between the two AKI-status subgroups. The multivariate logistic regression model indicated that the following factors were independently associated with AKI: multiorgan failure, presence of an underlying disorder, strong posi- tive urine occult blood, increased aspartate aminotransferase and uric acid levels, and reduced calcium levels. Conclusion: Our study revealed characteristic clinical and laboratory features of rhabdomyolysis in a Korean pediatric population and highlighted the risk factors for AKI in these cases. Our findings will contribute to a greater understanding of pediatric rhabdomyolysis and may enable early intervention against rhabdomyolysis-induced AKI.