부산대학교 도서관

In this study, mesenchymal progenitor-like cells (MPLCs) were derived from human induced pluripotentstem cells (hiPSCs) by retinoic acid (RA) treatment. In particular, RA induced hiPSC–derived MPLCs wereable to efficiently committed into osteogenic lineage cells. In addition, hiPSC–MPLCs were seeded ontothree-dimensional biomimetic scaffolds composed of hydroxyapatite and poly(L-lactic acid)/poly(lactic-co-glycolide) for assessing osteoinductivity, and enhanced osteogenic activities were perceived in RA-treatedcells in vitro and in vivo. In conclusion, addition of RA increased the osteogenic commitment potential ofhiPSCs–MPLCs and further applications with biomimetic composite scaffolds showed a promisingcombination for bone tissue engineering applications.